Las Manifestaciones cutáneas relacionadas con Pre diabetes y Diabetes mellitus: lo que el médico no debe olvidar
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oct 9, 2026
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https://doi.org/10.36677/medicinainvestigacion.v14i2.26991
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IVÁN RENATO ZÚÑIGA CARRASCO
http://orcid.org/0000-0002-8490-1978
http://orcid.org/0000-0002-8490-1978
Resumen
Lesiones cutáneas pueden proporcionar una visión temprana de la tolerancia a la glucosa del paciente y puede ser el primer signo de alteración metabólica. El reconocimiento temprano de estas alteraciones cutáneas y el tratamiento de la enfermedad sistémica subyacente del paciente pueden mejorar su calidad de vida y ayudar a prevenir complicaciones sistémicas graves asociadas con la resistencia a la insulina y la intolerancia a la glucosa. La acantosis nigricans es una manifestación dermatológica considerandose un indicador clínico significativo de resistencia a la insulina. Es importante mencionar que enfermedades de la piel como la psoriasis, la hidradenitis supurativa y el vitíligo se han asociado fuertemente con la resistencia a la insulina y el síndrome metabólico
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Article Details
Como citar
ZÚÑIGA CARRASCO, IVÁN RENATO.
Las Manifestaciones cutáneas relacionadas con Pre diabetes y Diabetes mellitus: lo que el médico no debe olvidar.
Medicina e Investigación Universidad Autónoma del Estado de México, [S.l.], v. 14, n. 2, p. 134-143, oct. 2026.
ISSN 2594-0600.
Disponible en: <https://medicinainvestigacion.uaemex.mx/article/view/26991>. Fecha de acceso: 13 oct. 2026
doi: https://doi.org/10.36677/medicinainvestigacion.v14i2.26991.
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Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
Citas
Malisiewicz B, Boehncke S, Lang V, Boehncke W, Buerger C. Epidermal Insulin Resistance as a Therapeutic Target in Acanthosis Nigricans? Acta Derm Venereol. 2014; 94: 607-608.
Napolitano M, Megna M, Giuseppe Monfrecola G. Insulin Resistance and Skin Diseases. Scientific World Journal. 2015: 479354.
Stefanadi E, Dimitrakakis G, Antoniou C, Challoumas D, Punjabi N, Dimitrakaki I et al. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decisión algorithm for high risk patients. Diabetol Metab Syndr. 2018; 10: 9.
Saldivar G, Rodrıguez R, Ocampo J, Gonzalez J, Gomez M. Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management. Dermatol Ther (Heidelb). 2017; 7: 37-51.
Adibi N, Robati R. Skin and metabolic syndrome: A review of the possible associations. J Res Med Sci. 2021; 26: 16.
Svoboda S, Shields B. Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin. Cutis. 2021; 107(2): 74-78.
Barbato M, Criado P, da Silva A, Averbeck E, Bensen M, Bittencourt N. Association of acanthosis nigricans and skin tags with insulin resistance. An Bras Dermatol. 2012; 87(1): 97-104.
Marchand L , Gaimard M, Luyton C. All about skin manifestations of insulin resistance and type 2 diabetes: acanthosis nigricans and acrochordons [Internet]. Postgrad Med J. 2020 abril; 96(1134): 237. doi: 10.1136/postgradmedj-2019-136834.
Mendes M, Teixeira P, Vanderlei D, Moura I, Duarte S, Andrade A, et al. Cutaneous manifestations of diabetes mellitus: a narrative review. Einstein (São Paulo). 2025;23:1-11
Mendonça M, Roda Â, Pimenta R, Leal P, Freitas J. Cutaneous Manifestations of Diabetes Mellitus and Prediabetes. Acta Med Port. 2019; 32(6): 459-465.
Ly L, Vo K, Cruel A, Shubrook J. Dermatological Manifestations of Diabetes Mellitus and Its Complications. Diabetology. 2025; 6 (3): 18.
Baselga E, Torres M. Manifestaciones cutáneas en niños con diabetes mellitus y obesidad. Actas Dermosifiliogr. 2014; 105(6): 546-557.
Van Hattem S, Bootsma A, Bing H. Skin manifestations of diabetes. Cleveland clinic journal of medicine. 2008; 7 5 (11); 772-787
Duff M, Demidova O, Blackburn S, Shubrook J. Cutaneous Manifestations of Diabetes Mellitus. Clinical. Diabetes journals. 2015; 33 (1): 40-48.
Crizón D, Morales C. Manifestaciones dermatológicas de la diabetes: clasificación y diagnóstico. Iatreia. 2020; 33(3): 239-50.
Andamari I, Bing H, Soebono H. Potential skin problems of diabetes mellitus patients: a review. J Med Sci. 2022; 54(3): 295-307.
González G, Rodríguez R, Ocampo J, González J, Gómez M. Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management. Dermatol Ther (Heidelb). 2017; 7: 37-51.
Rodrıguez R, de la O M, Salcido A, Sanchez A, Gomez M, Gonzalez V etal. Acanthosis Nigricans in the Knuckles of Infants: A Novel Clinical Marker of High Metabolic Risk. Diabetes Ther. 2019; 10(6): 2169-2181.
Jowkar F, Fallahi A, Namazi M. Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? J Eur Acad Dermatol Venereol. 2010; 24: 73-4.
Crook M. Skin tags and the atherogenic lipid profile. J Clin Pathol. 2000; 53: 873-4.
Tamega A, Aranha A, Guiotoku M, Miot L, Miot H. Associacao entre acrocordons e resistencia a insulina. An Bras Dermatol. 2010; 85: 25-31.
Reschke F, Biester T, von dem Berge T, Jamiolkowski D, Hasse L, Dassie F, et al. Skin manifestations in rare types of diabetes and other endocrine conditions. Endocrine Connections. 2023; 12: e220410.
Rodríguez R, Salcido A, Gonzalez J. Early Clinical Expressions of Insulin Resistance: The Real Enemy to Look For. Diabetes Ther. 2017; 16.
Fang C, Crowe C, Murphy A, O'Donnell M, Finucane F. Cross‑sectional study of the association between skin tags and vascular risk factors in a bariatric clinic‑based cohort of Irish adults with morbid obesity. BMC Res Notes. 2020; 16; 13(1): 156.
Napolitano M, Megna M, Giuseppe Monfrecola G. Insulin Resistance and Skin Diseases. Scientific World Journal. 2015: 479354.
Stefanadi E, Dimitrakakis G, Antoniou C, Challoumas D, Punjabi N, Dimitrakaki I et al. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decisión algorithm for high risk patients. Diabetol Metab Syndr. 2018; 10: 9.
Saldivar G, Rodrıguez R, Ocampo J, Gonzalez J, Gomez M. Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management. Dermatol Ther (Heidelb). 2017; 7: 37-51.
Adibi N, Robati R. Skin and metabolic syndrome: A review of the possible associations. J Res Med Sci. 2021; 26: 16.
Svoboda S, Shields B. Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin. Cutis. 2021; 107(2): 74-78.
Barbato M, Criado P, da Silva A, Averbeck E, Bensen M, Bittencourt N. Association of acanthosis nigricans and skin tags with insulin resistance. An Bras Dermatol. 2012; 87(1): 97-104.
Marchand L , Gaimard M, Luyton C. All about skin manifestations of insulin resistance and type 2 diabetes: acanthosis nigricans and acrochordons [Internet]. Postgrad Med J. 2020 abril; 96(1134): 237. doi: 10.1136/postgradmedj-2019-136834.
Mendes M, Teixeira P, Vanderlei D, Moura I, Duarte S, Andrade A, et al. Cutaneous manifestations of diabetes mellitus: a narrative review. Einstein (São Paulo). 2025;23:1-11
Mendonça M, Roda Â, Pimenta R, Leal P, Freitas J. Cutaneous Manifestations of Diabetes Mellitus and Prediabetes. Acta Med Port. 2019; 32(6): 459-465.
Ly L, Vo K, Cruel A, Shubrook J. Dermatological Manifestations of Diabetes Mellitus and Its Complications. Diabetology. 2025; 6 (3): 18.
Baselga E, Torres M. Manifestaciones cutáneas en niños con diabetes mellitus y obesidad. Actas Dermosifiliogr. 2014; 105(6): 546-557.
Van Hattem S, Bootsma A, Bing H. Skin manifestations of diabetes. Cleveland clinic journal of medicine. 2008; 7 5 (11); 772-787
Duff M, Demidova O, Blackburn S, Shubrook J. Cutaneous Manifestations of Diabetes Mellitus. Clinical. Diabetes journals. 2015; 33 (1): 40-48.
Crizón D, Morales C. Manifestaciones dermatológicas de la diabetes: clasificación y diagnóstico. Iatreia. 2020; 33(3): 239-50.
Andamari I, Bing H, Soebono H. Potential skin problems of diabetes mellitus patients: a review. J Med Sci. 2022; 54(3): 295-307.
González G, Rodríguez R, Ocampo J, González J, Gómez M. Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management. Dermatol Ther (Heidelb). 2017; 7: 37-51.
Rodrıguez R, de la O M, Salcido A, Sanchez A, Gomez M, Gonzalez V etal. Acanthosis Nigricans in the Knuckles of Infants: A Novel Clinical Marker of High Metabolic Risk. Diabetes Ther. 2019; 10(6): 2169-2181.
Jowkar F, Fallahi A, Namazi M. Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? J Eur Acad Dermatol Venereol. 2010; 24: 73-4.
Crook M. Skin tags and the atherogenic lipid profile. J Clin Pathol. 2000; 53: 873-4.
Tamega A, Aranha A, Guiotoku M, Miot L, Miot H. Associacao entre acrocordons e resistencia a insulina. An Bras Dermatol. 2010; 85: 25-31.
Reschke F, Biester T, von dem Berge T, Jamiolkowski D, Hasse L, Dassie F, et al. Skin manifestations in rare types of diabetes and other endocrine conditions. Endocrine Connections. 2023; 12: e220410.
Rodríguez R, Salcido A, Gonzalez J. Early Clinical Expressions of Insulin Resistance: The Real Enemy to Look For. Diabetes Ther. 2017; 16.
Fang C, Crowe C, Murphy A, O'Donnell M, Finucane F. Cross‑sectional study of the association between skin tags and vascular risk factors in a bariatric clinic‑based cohort of Irish adults with morbid obesity. BMC Res Notes. 2020; 16; 13(1): 156.