FACTORES DE RIESGO ASOCIADOS A ERC EN ETAPAS INCIPIENTES EN PACIENTES ADOLESCENTES, ATENDIDOS EN EL HOSPITAL GENERAL DE TLAXCALA 2019-2021
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sep 27, 2023
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https://doi.org/10.36677/medicinainvestigacion.v11i2.20676
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Claudia Nelly Orozco González
http://orcid.org/0000-0002-8885-5198
Antonieta Concepción Ávila Rodríguez
http://orcid.org/0009-0003-8708-2765
Héctor Manuel Sánchez Flores
http://orcid.org/0009-0006-9436-8317
http://orcid.org/0000-0002-8885-5198
Antonieta Concepción Ávila Rodríguez
http://orcid.org/0009-0003-8708-2765
Héctor Manuel Sánchez Flores
http://orcid.org/0009-0006-9436-8317
Resumen
Introducción: La prevalencia de enfermedad renal crónica está en aumento en adolescentes. Estos pacientes representan un desafío para la salud pública ya que se disminuye su calidad de vida y se aumentan los gastos en salud.
Objetivo: Determinar la prevalencia y los factores de riesgo asociados a ERC en etapas incipientes en pacientes adolescentes, atendidos en el Hospital General de Tlaxcala, en el periodo de enero de 2019 a junio de 2021.
Material y métodos: Se realizó un estudio analítico de casos y controles, en el Hospital General de Tlaxcala. Los casos tenían diagnóstico de ERC y los controles sin el diagnostico de ERC.
Resultados: En la comparación de casos y controles los casos tenían estadísticamente mayor presencia de diabetes (75% vs 34%), hipertensión arterial (91% vs 22%), exposición a aminoglucósido (59% vs 12%), además de vivir cerca de ríos (56% vs 19%), fábricas (66% vs 22%) y materiales pesados (59% vs 9%).
Conclusiones: La prevalencia fue de 6 pacientes con la enfermedad por cada mil atenciones durante el periodo del estudio. Las variables asociadas a la ERC fueron la menor talla, el mayor IMC, vivir expuestos a ríos, canales, fábricas y metales pesados, así como aminoglucósidos.
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OROZCO GONZÁLEZ, Claudia Nelly; ÁVILA RODRÍGUEZ, Antonieta Concepción; SÁNCHEZ FLORES, Héctor Manuel.
FACTORES DE RIESGO ASOCIADOS A ERC EN ETAPAS INCIPIENTES EN PACIENTES ADOLESCENTES, ATENDIDOS EN EL HOSPITAL GENERAL DE TLAXCALA 2019-2021.
Medicina e Investigación Universidad Autónoma del Estado de México, [S.l.], v. 11, n. 2, p. 33-40, sep. 2023.
ISSN 2594-0600.
Disponible en: <https://medicinainvestigacion.uaemex.mx/article/view/20676>. Fecha de acceso: 18 ago. 2026
doi: https://doi.org/10.36677/medicinainvestigacion.v11i2.20676.
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Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
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Gomez-Huelgas Ricardo, Martínez-Castelo Alberto, Artola Sara, Górriz José L., Menéndez Edelmiro. Documento de Consenso sobre el tratamiento de la diabetes tipo 2 en el paciente con enfermedad renal crónica, Revista Nefrología, 2014; 34 (1): 34-45. Disponible en: https://scielo.isciii.es/pdf/nefrologia/v34n1/especial2.pdf
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Hasslacher C, Ritz E, Wahl P, Michael C. Similar risks of nephropathy in pa-tients with type I or type II diabetes mellitus. Nephrol Dial Transplant. 1989; 4: 859-63. https://pubmed.ncbi.nlm.nih.gov/2515489/
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Ortega-Romero M, Méndez-Hernández P, Cruz-Angulo MDC, Hernán-dez-Sánchez AM, Álvarez-Elías AC, Muñoz-Arizpe R, et al. Chronic kidney disease in children aged 6-15 years and associated risk factors in Apizaco, Tlaxcala, Mexico, a pilot study. Nephron [Internet]. 2019; 143 (4): 264–73. Disponible en: https://www.karger.com/DOI/10.1159/000502481
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Ku E, Kwok J. Complications of Chronic Kidney Disease in Adolescents. En: Adolescents with Chronic Kidney Disease. Haddad M, Winnicki E, eds. Swit-zerland: Springer Nature AG. 2019: 1-15.
Becherucci F, Roperto RM, Materassi M, Romagnani P. Chronic kidney disease in children. Clin Kidney J [Internet]. 2016 [consultado el 24 de enero de 2023]; 9 (4): 583–91. Disponible en: https://academic.oup.com/ckj/arti-cle/9/4/583/2918815?login=false
Warady BA, Abraham AG, Schwartz GJ, Wong CS, Muñoz A, Betoko A, et al. Predictors of rapid progression of glomerular and nonglomerular kidney disease in children and adolescents: The Chronic Kidney Disease in children (CKiD) cohort. Am J Kidney Dis [Internet]. 2015 [consultado el 24 de enero de 2023]; 65 (6): 878–88. Disponible en: https://www.ajkd.org/article/S0272-6386(15)00090-6/fulltext
Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders H-J. Acute kidney injury. Nat Rev Dis Primers [Internet]. 2021 [consultado el 24 de enero de 2023]; 7 (1): 52. Disponible en: https://www.nature.com/articles/s41572-021-00284-z
Surachman A, Daw J, Bray BC, Alexander LM, Coe CL, Almeida DM. Child-hood socioeconomic status, comorbidity of chronic kidney disease risk factors, and kidney function among adults in the midlife in the United States (MIDUS) study. BMC Nephrol [Internet]. 2020; 21 (1): 188. Disponible en: http://dx.doi.org/10.1186/s12882-020-01846-1
Khalsa DDK, Beydoun HA, Carmody JB. Prevalence of chronic kidney disease risk factors among low birth weight adolescents. Pediatr Nephrol [Internet]. 2016; 31 (9): 1509–16. Disponible en: http://dx.doi.org/10.1007/s00467-016-3384-7
Hoste EAJ, Kellum JA, Selby NM, Zarbock A, Palevsky PM, Bagshaw SM, et al. Global epidemiology and outcomes of acute kidney injury. Nat Rev Nephrol [Internet]. 2018 [consultado el 24 de enero de 2023];14 (10): 607–25. Disponible en: https://www.nature.com/articles/s41581-018-0052-0
Stern-Zimmer M, Calderon-Margalit R, Skorecki K, Vivante A. Childhood risk factors for adulthood chronic kidney disease. Pediatr Nephrol [Internet]. 2021; 36 (6): 1387–96. Disponible en: http://dx.doi.org/10.1007/s00467-020-04611-6
Iseki K, Ikemiya Y, Kinjo K, Inoue T, Iseki C, Takishita S. Body mass index and the risk of development of end-stage renal disease in a screened cohort. Kidney Int 2004; 65: 1870-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15086929/
Kambham N, Markowitz GS, Valeri AM, Lin J, D’Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 2001; 59: 1498-509. Dis-ponible en: https://pubmed.ncbi.nlm.nih.gov/11260414/.
Bonnet F, Deprele C, Sassolas A, Moulin P, Alamartine E, Berthezene F, et al. Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA nephritis. Am J Kidney Dis 2001; 37: 720-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11273871/
Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for endstage renal disease. Ann Intern Med 2006; 144: 21-8. Dis-ponible en: consultado el 24 de en-ero de 2023]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16389251/
Kamath N, Iyengar A, George N, Luyckx VA. Risk factors and rate of progression of CKD in children. Kid-ney Int Rep [Internet]. 2019 [consultado el 24 de enero de 2023]; 4 (10): 1472–7. Disponible en: https://www.kireports.org/article/S2468-0249(19)31362-2/fulltext
Flynn JT, Mitsnefes M, Pierce C, Cole SR, Parekh RS, Furth SL, et al. Blood pressure in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children study: A report from the Chronic Kidney Disease in children study. Hypertension [Internet]. 2008; 52 (4): 631–7. Disponible en: http://dx-.doi.org/10.1161/HYPERTENSIONA-HA.108.110635
Atkinson MA, Ng DK, Warady BA, Furth SL, Flynn JT. The CKiD study: overview and summary of findings re-lated to kidney disease progression. Pediatr Nephrol [Internet]. 2021; 36 (3): 527–38. Disponible en:http://dx.doi.org/10.1007/s00467-019-04458-6
ESCAPE Trial Group, Wühl E, Triv-elli A, Picca S, Litwin M, Peco-An-tic A, et al. Strict blood-pressure control and progression of renal failure in children. N Engl J Med [Internet]. 2009; 361 (17): 1639–50. Disponible en:http://dx.doi.org/10.1056/NEJMoa0902066
He G, Li C, Zhong X, Wang F, Wang H, Shi Y, et al. Risk factors for progression of Chronic kidney disease with glomerular etiology in hospitalized chil-dren. Front Pediatr [Internet]. 2021; 9: 752717. Disponible en:http://dx.doi.org/10.3389/fped.2021.752717
Wong Lam Carolina, Toro Toro Elizabeth; 2021; Diabetes Mellitus, Edición Nelson A. Vargas Catalán, Pediatría para “NANEAS”. 2a Ed. 461-476 https://www.sochipe.cl/naneas/libro2021/PDF.pdf
Gomez-Huelgas Ricardo, Martínez-Castelo Alberto, Artola Sara, Górriz José L., Menéndez Edelmiro. Documento de Consenso sobre el tratamiento de la diabetes tipo 2 en el paciente con enfermedad renal crónica, Revista Nefrología, 2014; 34 (1): 34-45. Disponible en: https://scielo.isciii.es/pdf/nefrologia/v34n1/especial2.pdf
Rodriguez-Poncelas A, Garre-Olmo J, Franch-Nadal J, Diez-Espino J, Mun-det-Tuduri X, Barrot-de la Puente J, et al. Prevalence of chronic kidney disease in patients with type 2 diabetes in Spain: PERCEDIME2 study. BMC Nephrol 2013; 14:46. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23433046/
Hasslacher C, Ritz E, Wahl P, Michael C. Similar risks of nephropathy in pa-tients with type I or type II diabetes mellitus. Nephrol Dial Transplant. 1989; 4: 859-63. https://pubmed.ncbi.nlm.nih.gov/2515489/
Glanzmann C, Frey B, Vonbach P, Meier CR. Drugs as risk factors of acute kidney injury in critically ill children. Pediatr Nephrol [Internet]. 2016; 31 (1): 145–51. Disponible en: http://dx.doi.org/10.1007/s00467-015-3180-9
Ortega-Romero M, Méndez-Hernández P, Cruz-Angulo MDC, Hernán-dez-Sánchez AM, Álvarez-Elías AC, Muñoz-Arizpe R, et al. Chronic kidney disease in children aged 6-15 years and associated risk factors in Apizaco, Tlaxcala, Mexico, a pilot study. Nephron [Internet]. 2019; 143 (4): 264–73. Disponible en: https://www.karger.com/DOI/10.1159/000502481
Glaser, J., Lemery, J., Rajagopalan, B., Diaz, H.F. García-Trabanino, R., et al. Climate change and the emergente epidemic of CKD from heat stess in rural communities: The case for heat stress nephropathy. Clinical Journal of the American Society of Nephrology. 2016; 11 (8): 1472-1483. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27151892/
Xu X, Nie S, Ding H, Hou FF. En-vironmental pollution and kidney diseases. Nat Rev Nephrol [Inter-net]. 2018 [consultado el 24 de enero de 2023]; 14 (5): 313–24. Di-sponible en: https://www.nature.com/articles/nrneph.2018.11
Alabi OA, Adeoluwa YMHuo X, Xu X, Bakare AA Enviromental contamination, and public healt effects of electronic waste: an overview J Enviro Health Science and Engineering. 2021; 19: 1209-1227. Disponible en: https://doi.org/10.1007/s40201-021-00654-5
Obrador GT, Schultheiss UT, Kretzler M, Langham RG, Nangaku M, Pecoits-Filho R, et al. Genetic and environmental risk factors for chronic kidney disease. Kidney Int Suppl (2011) [Internet]. 2017 [con-sultado el 24 de enero de 2023]; 7 (2): 88–106. Disponible en: https://www.kisupplements.org/article/S2157-1716(17)30030-8/fulltex