Los marcadores de repetición corta en tándem como herramienta para estudios en salud pública en México
Article Sidebar
Publicado
abr 16, 2026
##plugins.pubIds.doi.readerDisplayName##
https://doi.org/10.36677/medicinainvestigacion.v14i1.25529
Main Article Content
MARTIN ABRAHAM REYES LARA
Crystian Sadiel Venegas Barrera
http://orcid.org/0000-0002-4290-0838
Víctor Jorge Horta Vega
http://orcid.org/0000-0002-5360-2684
Ángel Emmanuel Villanueva Chimal
http://orcid.org/0009-0009-2081-2392
Juan Flores Gracia
http://orcid.org/0000-0002-3490-6391
Netzahualcoyotl Mayek Pérez
http://orcid.org/0000-0001-6960-6287
http://orcid.org/0000-0002-4290-0838
Víctor Jorge Horta Vega
http://orcid.org/0000-0002-5360-2684
Ángel Emmanuel Villanueva Chimal
http://orcid.org/0009-0009-2081-2392
Juan Flores Gracia
http://orcid.org/0000-0002-3490-6391
Netzahualcoyotl Mayek Pérez
http://orcid.org/0000-0001-6960-6287
Resumen
Las repeticiones cortas en tándem (str) o microsatélites, son secuencias de adn de 2-7 nucleótidos que se repiten en el genoma humano. Los strs permiten estudiar enfermedades, la estructura de la población y estudios forenses. En esta revisión se analizaron los estudios donde se aplicaron strs en medicina y salud pública. En 834 publicaciones en PubMed (1993-2024), las dos principales aplicaciones de los strs fueron obtener frecuencias alélicas y la genética de poblaciones. El país con más artículos fue China (256). En la década del 2010 se publicaron 40 artículos en promedio por año. Se encontraron 47 artículos relacionados con 29 enfermedades, padecimientos y/o trastornos. La mayor cantidad de artículos en enfermedades se realizaron con poblaciones de Irán (4), México (3) y China (2); las enfermedades más frecuentemente estudiadas fueron el Cáncer, Distrofia muscular y Aneuploidías autosómicas. En México, los strs se aplicaron en Lepra Lepromatosa y la psoriasis en placas. Su uso en el estudio de enfermedades y estudios (identificación, genética de poblaciones, búsqueda de personas) serán los más frecuentes en el corto y mediano plazos, obteniendo información útil en estrategias y políticas en en salud pública, y así mejorar la calidad de vida de los mexicanos
Article Details
Como citar
REYES LARA, MARTIN ABRAHAM et al.
Los marcadores de repetición corta en tándem como herramienta para estudios en salud pública en México.
Medicina e Investigación Universidad Autónoma del Estado de México, [S.l.], v. 14, n. 1, p. 98-107, abr. 2026.
ISSN 2594-0600.
Disponible en: <https://medicinainvestigacion.uaemex.mx/article/view/25529>. Fecha de acceso: 18 ago. 2026
doi: https://doi.org/10.36677/medicinainvestigacion.v14i1.25529.
Número
Sección
Artículos de revisión
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
Citas
Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, et al. Genetic structure of human populations. Science (New York, NY). 2002; 298 (5602): 2381-5.
Kayser M, Branicki W, Parson W, Phillips C. Recent advances in Forensic DNA Phenotyping of appearance, ancestry and age. Forensic Science International: Genetics. 2023; 65.
González-Herrera L, Sosa-Escalante JE, López-González P, López-González MJ, Gamboa-Magaña RY, Herrera-Diaz RG, et al. Ancestral proportions based on 22 autosomal STRs of an admixed population (Mestizos) from the Península of Yucatán, México. Forensic Science International: Genetics Supplement Series. 2019; 7 (1): 429-31.
López-Ramírez YL, Aguilar-Velázquez JA, López-Armenta M, Ruiz-Hernández M, Rangel-Villalobos H. Paternal lineages and forensic parameters based on 23 Y-STRs (Powerplex® Y23) in Mestizo males from Mexico City. International journal of legal medicine. 2020; 134 (1): 199-202.
Keerti A, Ninave S. DNA Fingerprinting: Use of Autosomal Short Tandem Repeats in Forensic DNA Typing. Cureus. 2022; 14 (10): e30210.
Yang J, Chen J, Ji Q, Li K, Deng C, Kong X, et al. Could routine forensic STR genotyping data leak personal phenotypic information? Forensic Science International. 2022; 335: 1-7.
Liao X, Zhu W, Zhou J, Li H, Xu X, Zhang B, et al. Repetitive DNA sequence detection and its role in the human genome. Communications biology. 2023; 6 (1): 954.
Kornberg A, Bertsch LL, Jackson JF, Khorana HG. Enzymatic synthesis of deoxyribonucleic acid, xvi. Oligonucleotides as templates and the mechanism of their replication. Proceedings of the National Academy of Sciences of the United States of America. 1964; 51 (2): 315-23.
Ho EKH, Macrae F, Latta LC, Benner MJ, Sun C, Ebert D, et al. Intraspecific Variation in Microsatellite Mutation Profiles in Daphnia magna. Mol Biol Evol. 2019; 36 (9): 1942-54.
Butler JM, Willis S. Interpol review of forensic biology and forensic DNA typing 2016-2019. Forensic Science International: Synergy. 2020; 2: 352-67.
Bukyya JL, Tejasvi MLA, Avinash A, P CH, Talwade P, Afroz MM, et al. DNA Profiling in Forensic Science: A Review. Global medical genetics. 2021; 8 (4): 135-43.
Fan H, Chu JY. A brief review of short tandem repeat mutation. Genomics, proteomics & bioinformatics. 2007; 5 (1): 7-14.
Nayyer S, Jaiswal AK. DNAprofiling in forensic investigation– A review. IP International Journal of Forensic Medicine and Toxicological Sciences. 2023; 8 (1): 14-22.
M’charek A, Toom V, Jong L. The Trouble with Race in Forensic Identification. Science, Technology, & Human Values. 2020; 45 (5): 804-28.
Vigeland MD, Egeland T. Joint DNA-based disaster victim identification. Scientific Reports. 2021; 11 (1): 1-13.
Srikummool M, Srithawong S, Muisuk K, Sangkhano S, Suwannapoom C, Kampuansai J, et al. Forensic and genetic characterizations of diverse southern Thai populations based on 15 autosomal STRs. Scientific Reports. 2022; 12 (1): 1-11.
Devesse L, Davenport L, Syndercombe Court D, Ballard D. Biogeographical Ancestry Estimation from Autosomal Short Tandem Repeats in the Sequencing Era. 2023; 3 (4): 123-37.
Rodríguez-Rodríguez JE, Ioannidis AG, Medina-Muñoz SG, Barberena-Jonas C, Blanco-Portillo J, Quinto-Cortés CD, et al. The genetic legacy of the Manila galleon trade in Mexico. Philosophical Transactions of the Royal Society B: Biological Sciences. 2022; 377 (20200419): 1-10.
Verbiest MA, Lundström O, Xia F, Baudis M, Bilgin Sonay T, Anisimova M. Short tandem repeat mutations regulate gene expression in colorectal cancer. Scientific Reports. 2024; 14 (1): 3331.
Wyner N, Barash M, McNevin D. Forensic Autosomal Short Tandem Repeats and Their Potential Association With Phenotype. Frontiers in Genetics. 2020; 11: 1-7.
Bañuelos MM, Zavaleta YJA, Roldan A, Reyes R-J, Guardado M, Chavez Rojas B, et al. Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy. 2022; 119 (40): e2121024119.
Guevara EK, Palo JU, King JL, Buś MM, Guillén S, Budowle B, et al. Autosomal STR and SNP characterization of populations from the Northeastern Peruvian Andes with the ForenSeq™ DNA Signature Prep Kit. Forensic Science International: Genetics. 2021; 52: 102487.
Melo G, Uscanga K, López-Armenta M, Avilés-Villada D, Hernández-Romano P, Rangel-Villalobos H, et al. Use of Investigator 24plex GO! To analyse allele frequencies of 21 autosomal STRs in the population of Veracruz state, Mexico. Annals of Human Biology. 2022; 49 (2): 164-9.
Salinas-Pineda L, Berumen J, Lopez Armenta M, Leon Campos C, Rangel-Villalobos H, Juarez-Torres E, et al. Forensic parameters and population structure based on 21 autosomal STRs with the investigator 24plex QS in mestizos from the Mexico City population. Legal Medicine. 2024; 66: 102344.
García-Aceves ME, Romero Rentería O, Díaz-Navarro XX, Rangel-Villalobos H. Paternity tests in Mexico: Results obtained in 3005 cases. Journal of forensic and legal medicine. 2018; 55: 1-7.
Villa-Islas V, Izarraras-Gomez A, Larena M, Campos EMP, Sandoval-Velasco M, Rodríguez-Rodríguez JE, et al. Demographic history and genetic structure in pre-Hispanic Central Mexico. 2023; 380 (6645): eadd6142.
Hammer O, Harper D, Ryan P. PAST: Paleontological Statistics Software Package for Education and Data Analysis. Palaeontologia Electronica. 2001; 4: 1-9.
Butler JM. The future of forensic DNA analysis. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2015; 370 (1674): 1-10.
Sohail M, Palma-Martínez MJ, Chong AY, Quinto-Cortés CD, Barberena-Jonas C, Medina-Muñoz SG, et al. Mexican Biobank advances population and medical genomics of diverse ancestries. Nature. 2023; 622 (7984): 775-83.
Buniello A, MacArthur JAL, Cerezo M, Harris LW, Hayhurst J, Malangone C, et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 2019; 47 (D1): D1005-d12.
Shi Y, Niu Y, Zhang P, Luo H, Liu S, Zhang S, et al. Characterization of genome-wide STR variation in 6487 human genomes. Nature Communications. 2023;14(1):2092.
Xie N. Building a catalogue of short tandem repeats in diverse populations. Nature Reviews Genetics. 2024; 25 (7): 457-.
Kuri-Morales P, Emberson J, Alegre-Díaz J, Tapia-Conyer R, Collins R, Peto R, et al. The prevalence of chronic diseases and major disease risk factors at different ages among 150,000 men and women living in Mexico City: cross-sectional analyses of a prospective study. BMC Public Health. 2009; 9: 9.
González-León M, Fernández-Gárate JE, Rascón-Pacheco RA, Valladares-Aranda MÁ, Dávila-Torres J, Borja-Aburto VH. The burden of disease of cancer in the Mexican Social Security Institute. Salud Pública de México. 2016; 58 (2): 132-41.
Flores-Payan L, Hernández-Corona DM, González-Heredia T. Multidimensional analysis of health in Mexico: implementation of fuzzy sets. BMC Public Health. 2021; 21 (1): 944.
Kayser M, Branicki W, Parson W, Phillips C. Recent advances in Forensic DNA Phenotyping of appearance, ancestry and age. Forensic Science International: Genetics. 2023; 65.
González-Herrera L, Sosa-Escalante JE, López-González P, López-González MJ, Gamboa-Magaña RY, Herrera-Diaz RG, et al. Ancestral proportions based on 22 autosomal STRs of an admixed population (Mestizos) from the Península of Yucatán, México. Forensic Science International: Genetics Supplement Series. 2019; 7 (1): 429-31.
López-Ramírez YL, Aguilar-Velázquez JA, López-Armenta M, Ruiz-Hernández M, Rangel-Villalobos H. Paternal lineages and forensic parameters based on 23 Y-STRs (Powerplex® Y23) in Mestizo males from Mexico City. International journal of legal medicine. 2020; 134 (1): 199-202.
Keerti A, Ninave S. DNA Fingerprinting: Use of Autosomal Short Tandem Repeats in Forensic DNA Typing. Cureus. 2022; 14 (10): e30210.
Yang J, Chen J, Ji Q, Li K, Deng C, Kong X, et al. Could routine forensic STR genotyping data leak personal phenotypic information? Forensic Science International. 2022; 335: 1-7.
Liao X, Zhu W, Zhou J, Li H, Xu X, Zhang B, et al. Repetitive DNA sequence detection and its role in the human genome. Communications biology. 2023; 6 (1): 954.
Kornberg A, Bertsch LL, Jackson JF, Khorana HG. Enzymatic synthesis of deoxyribonucleic acid, xvi. Oligonucleotides as templates and the mechanism of their replication. Proceedings of the National Academy of Sciences of the United States of America. 1964; 51 (2): 315-23.
Ho EKH, Macrae F, Latta LC, Benner MJ, Sun C, Ebert D, et al. Intraspecific Variation in Microsatellite Mutation Profiles in Daphnia magna. Mol Biol Evol. 2019; 36 (9): 1942-54.
Butler JM, Willis S. Interpol review of forensic biology and forensic DNA typing 2016-2019. Forensic Science International: Synergy. 2020; 2: 352-67.
Bukyya JL, Tejasvi MLA, Avinash A, P CH, Talwade P, Afroz MM, et al. DNA Profiling in Forensic Science: A Review. Global medical genetics. 2021; 8 (4): 135-43.
Fan H, Chu JY. A brief review of short tandem repeat mutation. Genomics, proteomics & bioinformatics. 2007; 5 (1): 7-14.
Nayyer S, Jaiswal AK. DNAprofiling in forensic investigation– A review. IP International Journal of Forensic Medicine and Toxicological Sciences. 2023; 8 (1): 14-22.
M’charek A, Toom V, Jong L. The Trouble with Race in Forensic Identification. Science, Technology, & Human Values. 2020; 45 (5): 804-28.
Vigeland MD, Egeland T. Joint DNA-based disaster victim identification. Scientific Reports. 2021; 11 (1): 1-13.
Srikummool M, Srithawong S, Muisuk K, Sangkhano S, Suwannapoom C, Kampuansai J, et al. Forensic and genetic characterizations of diverse southern Thai populations based on 15 autosomal STRs. Scientific Reports. 2022; 12 (1): 1-11.
Devesse L, Davenport L, Syndercombe Court D, Ballard D. Biogeographical Ancestry Estimation from Autosomal Short Tandem Repeats in the Sequencing Era. 2023; 3 (4): 123-37.
Rodríguez-Rodríguez JE, Ioannidis AG, Medina-Muñoz SG, Barberena-Jonas C, Blanco-Portillo J, Quinto-Cortés CD, et al. The genetic legacy of the Manila galleon trade in Mexico. Philosophical Transactions of the Royal Society B: Biological Sciences. 2022; 377 (20200419): 1-10.
Verbiest MA, Lundström O, Xia F, Baudis M, Bilgin Sonay T, Anisimova M. Short tandem repeat mutations regulate gene expression in colorectal cancer. Scientific Reports. 2024; 14 (1): 3331.
Wyner N, Barash M, McNevin D. Forensic Autosomal Short Tandem Repeats and Their Potential Association With Phenotype. Frontiers in Genetics. 2020; 11: 1-7.
Bañuelos MM, Zavaleta YJA, Roldan A, Reyes R-J, Guardado M, Chavez Rojas B, et al. Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy. 2022; 119 (40): e2121024119.
Guevara EK, Palo JU, King JL, Buś MM, Guillén S, Budowle B, et al. Autosomal STR and SNP characterization of populations from the Northeastern Peruvian Andes with the ForenSeq™ DNA Signature Prep Kit. Forensic Science International: Genetics. 2021; 52: 102487.
Melo G, Uscanga K, López-Armenta M, Avilés-Villada D, Hernández-Romano P, Rangel-Villalobos H, et al. Use of Investigator 24plex GO! To analyse allele frequencies of 21 autosomal STRs in the population of Veracruz state, Mexico. Annals of Human Biology. 2022; 49 (2): 164-9.
Salinas-Pineda L, Berumen J, Lopez Armenta M, Leon Campos C, Rangel-Villalobos H, Juarez-Torres E, et al. Forensic parameters and population structure based on 21 autosomal STRs with the investigator 24plex QS in mestizos from the Mexico City population. Legal Medicine. 2024; 66: 102344.
García-Aceves ME, Romero Rentería O, Díaz-Navarro XX, Rangel-Villalobos H. Paternity tests in Mexico: Results obtained in 3005 cases. Journal of forensic and legal medicine. 2018; 55: 1-7.
Villa-Islas V, Izarraras-Gomez A, Larena M, Campos EMP, Sandoval-Velasco M, Rodríguez-Rodríguez JE, et al. Demographic history and genetic structure in pre-Hispanic Central Mexico. 2023; 380 (6645): eadd6142.
Hammer O, Harper D, Ryan P. PAST: Paleontological Statistics Software Package for Education and Data Analysis. Palaeontologia Electronica. 2001; 4: 1-9.
Butler JM. The future of forensic DNA analysis. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2015; 370 (1674): 1-10.
Sohail M, Palma-Martínez MJ, Chong AY, Quinto-Cortés CD, Barberena-Jonas C, Medina-Muñoz SG, et al. Mexican Biobank advances population and medical genomics of diverse ancestries. Nature. 2023; 622 (7984): 775-83.
Buniello A, MacArthur JAL, Cerezo M, Harris LW, Hayhurst J, Malangone C, et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 2019; 47 (D1): D1005-d12.
Shi Y, Niu Y, Zhang P, Luo H, Liu S, Zhang S, et al. Characterization of genome-wide STR variation in 6487 human genomes. Nature Communications. 2023;14(1):2092.
Xie N. Building a catalogue of short tandem repeats in diverse populations. Nature Reviews Genetics. 2024; 25 (7): 457-.
Kuri-Morales P, Emberson J, Alegre-Díaz J, Tapia-Conyer R, Collins R, Peto R, et al. The prevalence of chronic diseases and major disease risk factors at different ages among 150,000 men and women living in Mexico City: cross-sectional analyses of a prospective study. BMC Public Health. 2009; 9: 9.
González-León M, Fernández-Gárate JE, Rascón-Pacheco RA, Valladares-Aranda MÁ, Dávila-Torres J, Borja-Aburto VH. The burden of disease of cancer in the Mexican Social Security Institute. Salud Pública de México. 2016; 58 (2): 132-41.
Flores-Payan L, Hernández-Corona DM, González-Heredia T. Multidimensional analysis of health in Mexico: implementation of fuzzy sets. BMC Public Health. 2021; 21 (1): 944.